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This book presents up-to-date practically oriented information on major topics in acute hepatitis. The coverage encompasses epidemiology; diagnosis including molecular methods; treatment and challenges; and the management of co-infections. The book opens by examining the local and global epidemiology of acute hepatitis. Detailed attention is then paid to each of acute hepatitis A acute hepatitis B acute hepatitis C hepatitis D co-infection and hepatitis E. Acute Hepatitis will be of high value for general practitioners and specialists in gastroenterology infectious diseases and internal medicine. It will be international in scope in terms of both authorship and appeal.

This book presents up-to-date practically oriented information on major topics in acute hepatitis. The coverage encompasses epidemiology; diagnosis including molecular methods; treatment and challenges; and the management of co-infections. The book opens by examining the local and global epidemiology of acute hepatitis. Detailed attention is then paid to each of acute hepatitis A acute hepatitis B acute hepatitis C hepatitis D co-infection and hepatitis E. Acute Hepatitis will be of high value for general practitioners and specialists in gastroenterology infectious diseases and internal medicine. It will be international in scope in terms of both authorship and appeal.

This book presents up-to-date practically oriented information on major topics in chronic hepatitis C. The coverage encompasses epidemiology; diagnosis including molecular methods; treatment and challenges; and the management of co-infections. Readers will find guidance on pretherapeutic evaluation with respect to disease severity and extrahepatic manifestations. Resistance to antiviral treatment and its management are discussed and the nature of optimal follow-up is addressed in detail. Treatment of HCV/HIV co-infection is considered separately and the approach in special patient populations is thoroughly examined. Chronic Hepatitis C will be of high value for general practitioners and specialists in gastroenterology infectious diseases and internal medicine. It will be international in scope in terms of both authorship and appeal.

This book presents up-to-date practically oriented information on major topics in chronic hepatitis B. The coverage encompasses epidemiology; diagnosis including molecular methods; treatment and challenges; and the management of co-infections. Readers will also find guidance on the invasive and non-invasive assessment of fibrosis in HBV infection and the prevention of mother-to-child transmission of HBV. Management of chronic hepatitis B in children is considered separately and emerging drugs that hold promise for the treatment of chronic HBV infection are discussed. Chronic Hepatitis B will be of high value for general practitioners and specialists in gastroenterology infectious diseases and internal medicine. It will be international in scope in terms of both authorship and appeal.

This book presents up-to-date practically oriented information on major topics in chronic hepatitis B. The coverage encompasses epidemiology; diagnosis including molecular methods; treatment and challenges; and the management of co-infections. Readers will also find guidance on the invasive and non-invasive assessment of fibrosis in HBV infection and the prevention of mother-to-child transmission of HBV. Management of chronic hepatitis B in children is considered separately and emerging drugs that hold promise for the treatment of chronic HBV infection are discussed. Chronic Hepatitis B will be of high value for general practitioners and specialists in gastroenterology infectious diseases and internal medicine. It will be international in scope in terms of both authorship and appeal.

This book presents up-to-date practically oriented information on major topics in chronic hepatitis C. The coverage encompasses epidemiology; diagnosis including molecular methods; treatment and challenges; and the management of co-infections. Readers will find guidance on pretherapeutic evaluation with respect to disease severity and extrahepatic manifestations. Resistance to antiviral treatment and its management are discussed and the nature of optimal follow-up is addressed in detail. Treatment of HCV/HIV co-infection is considered separately and the approach in special patient populations is thoroughly examined. Chronic Hepatitis C will be of high value for general practitioners and specialists in gastroenterology infectious diseases and internal medicine. It will be international in scope in terms of both authorship and appeal.

Hepatitis viruses research started more than fifty years ago. The names of hepatitis A and hepatitis B were introduced in 1947 when it became clear that there were two types of hepatitis that were transmitted either enterically or parenterally. It became apparent in the 1970's that there were additional hepatitis viruses distinct from hepatitis A and hepatitis B and thus the term non-A non-B hepatitis was introduced. The non-A non-B hepatitis was further divided into post-transfusion non-A non-B hepatitis and enterically-transmitted non-A non-B hepatitis in the 1980's. By the end of the 1980's both post-transfusion non-A non-B virus and enterically-transmitted non-A non-B virus had been identified and renamed hepatitis C virus and hepatitis E virus respectively. Hepatitis delta antigen was first recognized as an antigen associated with hepatitis B virus infection in the 1970's. In the early 1980's a virus was isolated and named hepatitis delta virus. These five different hepatitis viruses have distinct replication pathways and are major health concerns. They have become an important topic for teaching to graduate-level and medical students. Hepatitis Viruses provides a comprehensive up-to-date review of these viruses to readers. Each chapter is written by one of the top researchers in the field and topics include: the epidemiology and the natural history of infection of these viruses the molecular biology and the replication cycle of individual hepatitis viruses host-virus interactions and the pathogenesis of hepatitis viruses the immunology of hepatitis viruses the relationship between hepatitis viruses and hepatocellular carcinoma the viral vaccines and antiviral drugs. This book can serve as a supplemental reading material to graduate students and medical students and to any researcher who would like to learn more about hepatitis viruses.

This book presents up-to-date practically oriented information on major topics in chronic hepatitis B. The coverage encompasses epidemiology; diagnosis including molecular methods; treatment and challenges; and the management of co-infections. Readers will also find guidance on the invasive and non-invasive assessment of fibrosis in HBV infection and the prevention of mother-to-child transmission of HBV. Management of chronic hepatitis B in children is considered separately and emerging drugs that hold promise for the treatment of chronic HBV infection are discussed. Chronic Hepatitis B will be of high value for general practitioners and specialists in gastroenterology infectious diseases and internal medicine. It will be international in scope in terms of both authorship and appeal.

By providing a compilation of cutting-edge research techniques currently used in HCV labs worldwide this book fully updates the previous edition. It reflects the progress which promises to unlock the remaining vital information regarding this human pathogen.

By providing a compilation of cutting-edge research techniques currently used in HCV labs worldwide this book fully updates the previous edition. It reflects the progress which promises to unlock the remaining vital information regarding this human pathogen.

Focusing on practical patient related issues this book is a useful practical resource for physicians managing patients diagnosed with autoimmune hepatitis both acutely and long-term. The contents are structured to emphasize useful management advice.

This volume serves as a reference for the dissemination of advances made in the study of Hepatitis B Virus (HBV). Hepatitis B Virus: Methods and Protocols details protocols and techniques ranging from cell culture studies to in vivo and clinical immunology. The chapters in this book discuss treatments of in vitro infection systems analysis and quantification of cccDNA and its mutations; in vitro polymerase activity assays; cellular trafficking of core proteins; intracellular calcium metabolism; detection cloning and sequencing of HBV markers; and new strategies aimed at exploiting new mechanisms for drug discovery. The book also covers classical methods for resolution of extracellular viral particles by native gel electrophoresis and methods for detecting HBV antigens in drug discovery. Written in the highly successful Methods in Molecular Biology series format chapters include introductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive Hepatitis B Virus: Methods and Protocols is a valuable tool for researchers to use toward their advanced studies in HBV.

Leading international virologists review the state-of-the-art in the biology pathogenesis and epidemiology of the hepatitis viruses. The authorities writing here examine the five well-recognized hepatitis viruses A through E and some of the newer agents the so-called non- A-E hepatitis viruses. They also provide in-depth discussions of the biological nature of the viruses the pathogenesis of the acute and chronic diseases they cause the methods and ease with which they are transmitted and their clinical signs and symptoms. Additional topics include diagnostic tests and routine blood screening new vaccines and the use of interferon and antiviral drugs. Viral Hepatitis: Diagnosis Therapy and Prevention provides the most comprehensive and up-to-date survey of the hepatitis viruses currently available

This book helps scientists clinicians and other interested individuals understand recent clinical advances and challenges for the future. It covers many basic aspects of the pathogenesis of chronic hepatitis C HCV infections in particular populations approaches to therapy and prevention and control of HCV Infection. The book provides a succinct review of the large amount of data generated by multiple groups over the past two decades that has revealed the natural history of HCV infection. Similarly it summarizes current understanding of the origins of HCV-associated hepatocellular carcinoma cirrhosis and hepatic fibrosis. Extra-hepatic manifestation and metabolic disorders related to HCV infection are described. In this volume these clinically important aspects of HCV infection are comprehensively described. Highlights are description of newly developed direct- acting antivirals. The authors represent a worldwide distribution of leaders in the field reflecting the global nature of HCV infection. Based on recent data concerning the genetic- and geographical diversity of HCV and increased global disease burden of HCV infection challenges for global control of HCV infections are described.

This volume serves as a reference for the dissemination of advances made in the study of Hepatitis B Virus (HBV). Hepatitis B Virus: Methods and Protocols details protocols and techniques ranging from cell culture studies to in vivo and clinical immunology. The chapters in this book discuss treatments of in vitro infection systems analysis and quantification of cccDNA and its mutations; in vitro polymerase activity assays; cellular trafficking of core proteins; intracellular calcium metabolism; detection cloning and sequencing of HBV markers; and new strategies aimed at exploiting new mechanisms for drug discovery. The book also covers classical methods for resolution of extracellular viral particles by native gel electrophoresis and methods for detecting HBV antigens in drug discovery. Written in the highly successful Methods in Molecular Biology series format chapters include introductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive Hepatitis B Virus: Methods and Protocols is a valuable tool for researchers to use toward their advanced studies in HBV.

This volume is composed of chapters that review important fundamental aspects of HCV biology and disease pathogenesis including for example the discovery and identification of the HCV genome early virus-cell interactions including identification of various cellular receptors HCV gene expression studied using the HCV replicon system identification and characterization of HCV structural- and non-structural HCV proteins HCV replication in cultured cells and host factors involved in viral replication. This volume also contains chapters dealing with immunity to HCV infection and pathogenesis. This is particularly important in understanding hepatitis C because HCV infection alone is not cell lytic. Mechanisms underlying the persistent nature of HCV infection are also discussed in these chapters. Many of the authors published articles that were listed among the top 10 papers published in the 24 years since HCV was discovered in 1989. Their citations are above 1 000 (Web of Science). The authors describe the background and significance of their contributions to the field in the context of findings from other research groups.

Chronic viral hepatitis affect hundreds of millions of people worldwide and each year millions more people become infected. In Chronic Viral Hepatitis Second Edition a panel of distinguished clinicians and clinical investigators build upon the first edition by comprehensively reviewing all the relevant new information regarding resistance side effects and therapies for chronic viral hepatitis. The text covers recent advances in the understanding of pathogenesis of viral hepatitis while discussing promising agents in development for its treatment. The authors devote special attention to reactivation of hepatitis B with chemotherapy and immunosuppression herbal and non-traditional therapies chronic viral hepatitis in the pediatric population and immunology and immunotherapy of HCV and provide relative costs for all diagnostic and therapeutic options. Authoritative and up-to-date Chronic Viral Hepatitis Second Edition offers today's gastroenterologists internists hepatologists and infectious disease specialists a practical guide to the recognition diagnosis and treatment of chronic viral hepatitis from a multidisciplinary approach.

Leading international virologists review the state-of-the-art in the biology pathogenesis and epidemiology of the hepatitis viruses. The authorities writing here examine the five well-recognized hepatitis viruses A through E and some of the newer agents the so-called non- A-E hepatitis viruses. They also provide in-depth discussions of the biological nature of the viruses the pathogenesis of the acute and chronic diseases they cause the methods and ease with which they are transmitted and their clinical signs and symptoms. Additional topics include diagnostic tests and routine blood screening new vaccines and the use of interferon and antiviral drugs. Viral Hepatitis: Diagnosis Therapy and Prevention provides the most comprehensive and up-to-date survey of the hepatitis viruses currently available

Hepatitis delta virus which causes severe acute and chronic liver disease was discovered following the detection of a novel antigen-antibody system in hepatitis B virus carriers. Currently HDV is classified as a subviral satellite of hepatitis B virus. However unlike other satellite viruses the dependence of HDV on HBV is limited solely to the provision of an envelope of hepatitis B surface antigen for virus assembly. Research into the molecular virology of the HDV life cycle has revealed a fascinating collection of biology. These insights are now beginning to be translated into new potential treatment strategies. There are currently still an estimated 15 million HDV carriers worldwide.

Hepatitis delta virus which causes severe acute and chronic liver disease was discovered following the detection of a novel antigen-antibody system in hepatitis B virus carriers. Currently HDV is classified as a subviral satellite of hepatitis B virus. However unlike other satellite viruses the dependence of HDV on HBV is limited solely to the provision of an envelope of hepatitis B surface antigen for virus assembly. Research into the molecular virology of the HDV life cycle has revealed a fascinating collection of biology. These insights are now beginning to be translated into new potential treatment strategies. There are currently still an estimated 15 million HDV carriers worldwide.