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The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes - Mechanisms and Models of Drug Interactions and Antimicrobial Drug Interactions. This volume Antimicrobial Drug Interactions delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial antimycobacterial antiviral antifungal antimalarial and antiprotozoal class. In line with current innovations in antimicrobial drug development a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-relatedinfections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.

Binding : Gebundene Ausgabe, Edition : 01, Label : Thames & Hudson Ltd, Publisher : Thames & Hudson Ltd, PackageQuantity : 1, medium : Gebundene Ausgabe, numberOfPages : 360, publicationDate : 2015-08-24, authors : Marco Spies, languages : english, ISBN : 0500518173

In this volume expert researchers in the field detail many of the methods which are now commonly used to study RNA. These methods are presented as a guidebook to scientists who are experienced with RNA research and want to brush up on a new technique. Written in the highly successful Methods in Molecular Biology series format chapters include introductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.Thorough and intuitive RNA-RNA Interactions: Methods and Protocols guides scientists investigating biological systems and studying RNA.

The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes - Mechanisms and Models of Drug Interactions and Antimicrobial Drug Interactions. This volume Mechanisms and Models of Drug Interactions delivers a text that enhances clinical knowledge of the complex mechanisms risks and consequences of drug interactions associated with antimicrobials infection and inflammation. The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature including materials focused on the complex interrelationship of acute infection inflammation and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions isincluded along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.

Binding : Gebundene Ausgabe, Edition : 1, Label : Schmidt Hermann Verlag, Publisher : Schmidt Hermann Verlag, medium : Gebundene Ausgabe, numberOfPages : 356, publicationDate : 2012-10-20, authors : Marco Spies, languages : german, ISBN : 3874398307

Binding : Taschenbuch, Edition : 5., Label : Wiley, Publisher : Wiley, medium : Taschenbuch, numberOfPages : 656, publicationDate : 2019-05-10, authors : Helen Sharp, Jennifer Preece, Yvonne Rogers, ISBN : 1119547253

Dr. Tom Moss assembles the new standard collection of cutting-edge techniques to identify key protein-DNA interactions and define their components their manner of interaction and their manner of function both in the cell and in the test tube. The techniques span a wide range from factor identification to atomic detail and include multiple DNA footprinting analyses including in vivo strategies gel shift (EMSA) optimization SELEX surface plasmon resonance site-specific DNA-protein crosslinking and UV laser crosslinking. Comprehensive and broad ranging DNA-Protein Interactions: Principles and Protocols 2nd Edition offers a stellar array of over 100 up-to-date and readily reproducible techniques that biochemists and molecular cellular and developmental biologists can use successfully today to understand DNA-protein interactions. DNA-protein interactions are fundamental to understanding biological growth development differentiation evolution and disease and are also increasingly important to the biotechnology industry. In DNA-Protein Interactions: Principles and Protocols 2nd Edition Dr. Tom Moss assembles the new standard collection of cutting-edge techniques to identify key protein-DNA interactions define their components and determine the nature of their interactions and their manner of function both in the cell and in the test tube. Each detailed method has been optimized and tested by a hands-on expert to ensure experimental success and provides helpful notes on pitfalls to avoid as well as alternate strategies. The techniques span a wide range from factor identification to atomic detail and include multiple DNA footprinting analyses including in vivo strategies gel shift (EMSA) optimization SELEX surface plasmon resonance site-specific DNA-protein crosslinking and UV laser crosslinking. There are also vanguard methods for designing proteins to fit DNA site-specific protein-directed DNA cleavage and 2D semicrystalline arrays of nucleoproteins for structure determination. Comprehensive and broad ranging DNA-Protein Interactions: Principles and Protocols 2nd Edition offers a stellar array of over 100 up-to-date and readily reproducible techniques that biochemists and molecular cellular and developmental biologists can use successfully today to illuminate DNA-protein interactions.

Binding : Taschenbuch, Edition : Revised., Label : Sage Publications, Incorporated, Publisher : Sage Publications, Incorporated, NumberOfItems : 1, PackageQuantity : 1, medium : Taschenbuch, numberOfPages : 380, publicationDate : 1995-10-06, authors : Brislin, Richard W., languages : english, ISBN : 0803959915

The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes - Mechanisms and Models of Drug Interactions and Antimicrobial Drug Interactions. This volume Antimicrobial Drug Interactions delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial antimycobacterial antiviral antifungal antimalarial and antiprotozoal class. In line with current innovations in antimicrobial drug development a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-relatedinfections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.

As the mysteries stored in our DNA have been more completely revealed scientists have begun to face the extraordinary challenge of unraveling the int- cate network of protein-protein interactions established by that DNA fra- work. It is increasingly clear that proteins continuously interact with one another in a highly regulated fashion to determine cell fate such as proliferation diff- entiation or death. These protein-protein interactions enable and exert str- gent control over DNA replication RNA transcription protein translation macromolecular assembly and degradation and signal transduction; essentially all cellular functions involve protein-protein interactions. Thus protein-p- tein interactions are fundamental for normal physiology in all organisms. Alt- ation of critical protein-protein interactions is thought to be involved in the development of many diseases such as neurodegenerative disorders cancers and infectious diseases. Therefore examination of when and how protein-p- tein interactions occur and how they are controlled is essential for understa- ing diverse biological processes as well as for elucidating the molecular basis of diseases and identifying potential targets for therapeutic interventions. Over the years many innovative biochemical biophysical genetic and computational approaches have been developed to detect and analyze p- tein-protein interactions. This multitude of techniques is mandated by the diversity of physical and chemical properties of proteins and the sensitivity of protein-protein interactions to cellular conditions.

Binding : Taschenbuch, Edition : Second, Label : WW Norton & Co, Publisher : WW Norton & Co, NumberOfItems : 1, medium : Taschenbuch, numberOfPages : 648, publicationDate : 2012-10-19, authors : Frieden, Jeffrey A., ISBN : 0393920836

The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes - Mechanisms and Models of Drug Interactions and Antimicrobial Drug Interactions. This volume Mechanisms and Models of Drug Interactions delivers a text that enhances clinical knowledge of the complex mechanisms risks and consequences of drug interactions associated with antimicrobials infection and inflammation. The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature including materials focused on the complex interrelationship of acute infection inflammation and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions isincluded along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.

A versatile collection of readily reproducible cell-cell interaction assays for uncovering cellular interactions at the molecular level both in vitro and in vivo. The protocols cover a diverse set of cell-cell interaction models in both normal and pathological states are readily adaptable to nearly any cell type and organ system and include primary data and outcome analysis. In addition the protocols follow the successful Methods in Molecular Biology(TM) series format each offering step-by-step laboratory instructions an introduction outlining the principles behind the technique lists of the necessary equipment and reagents and tips on troubleshooting and avoiding known pitfalls.

Binding : Taschenbuch, Label : Dunod, Publisher : Dunod, NumberOfItems : 1, medium : Taschenbuch, publicationDate : 2003-04-10, authors : Deepak Chopra, languages : french, ISBN : 210007055X

The 3 volume-set LNCS 10901 10902 + 10903 constitutes the refereed proceedings of the 20th International Conference on Human-Computer Interaction HCI 2018 which took place in Las Vegas Nevada in July 2018. The total of 1171 papers and 160 posters included in the 30 HCII 2018 proceedings volumes was carefully reviewed and selected from 4346 submissions. HCI 2018 includes a total of 145 papers; they were organized in topical sections named: Part I: HCI theories methods and tools; perception and psychological issues in HCI; emotion and attention recognition; security privacy and ethics in HCI. Part II: HCI in medicine; HCI for health and wellbeing; HCI in cultural heritage; HCI in complex environments; mobile and wearable HCI. Part III: input techniques and devices; speech-based interfaces and chatbots; gesture motion and eye-tracking based interaction; games and gamification.

This volume successfully and clearly examines how biophysical approaches can be used to study complex systems of reversibly interacting proteins. It deals with the methodology behind the research and shows how to synergistically incorporate several methodologies for use. Each chapter treats and introduces the reader to different biological systems includes a brief summary of the physical principles and mentions practical requirements.

Brand : Independently Published, Binding : Taschenbuch, Edition : Illustrated, Label : Independently published, Publisher : Independently published, PackageQuantity : 1, Format : Illustriert, medium : Taschenbuch, numberOfPages : 199, publicationDate : 2019-02-17, authors : Jakob Schwichtenberg, ISBN : 1795882417

The 3 volume-set LNCS 10901 10902 + 10903 constitutes the refereed proceedings of the 20th International Conference on Human-Computer Interaction HCI 2018 which took place in Las Vegas Nevada in July 2018. The total of 1171 papers and 160 posters included in the 30 HCII 2018 proceedings volumes was carefully reviewed and selected from 4346 submissions. HCI 2018 includes a total of 145 papers; they were organized in topical sections named: Part I: HCI theories methods and tools; perception and psychological issues in HCI; emotion and attention recognition; security privacy and ethics in HCI. Part II: HCI in medicine; HCI for health and wellbeing; HCI in cultural heritage; HCI in complex environments; mobile and wearable HCI. Part III: input techniques and devices; speech-based interfaces and chatbots; gesture motion and eye-tracking based interaction; games and gamification.

In its revised 2nd Edition this Methods in Molecular Biology(TM) book provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. Offers materials lists reproducible protocols notes and more.

Binding : Taschenbuch, Label : Independently published, Publisher : Independently published, medium : Taschenbuch, numberOfPages : 244, publicationDate : 2019-10-22, authors : Ocean Ramsey, ISBN : 1701890399