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Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory or population studies into clinical application to reduce incidence of cancer , morbidity and mortality. It is becoming increasingly evident that cancer is a preventable disease. The IVth International Symposium on Translational Cancer Research held in Udaipur, India in December 2011, discussed various aspects of the biological processes in cancer cells and approaches to cancer prevention. A few contributions from this meeting are presented in this book, providing an in depth analysis of data on cancer prevention and therapeutics. These contributions are either critical reviews or research reports. The topics discussed include evidence-based nutritional recommendations for cancer patients and survivors, risk factors such as stress, enrichment of tumour stem cells by anticancer drug treatment contributing to tumour recurrence and the mechanism of anticancer effects of various natural products. Chemosensitizing effect of curcumin, anti-cancer effect of products from neem, action of sulforaphane and cytotoxic effect of a number of novel synthetic coordination complexes of trace metals have been discussed. Novel molecular targets of angiogenesis and molecular basis of the gender bias to thyroid cancer have also been discussed . This book provides useful information on translational cancer research to clinicians and biomedical scientists.

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This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.

In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.

Introduces young readers to conditions and disabilities that may affect them, or their friends and family. Each title discusses what the condition is, how it can be treated, how it affects everyday life and what it is like to have these conditions. This book contains a clear definition of each illness or condition and includes a 'how you can help' section offering contact details and further information and advice.

Ein neues Verständnis von Krebs und seiner HeilungDie Filmemacherin Susanne Aernecke begibt sich auf die Suche nach alternativen Krebsheilmethoden. Von Spanien führt sie der Weg ins indische Kalkutta zur Ärztefamilie Banerji, die in den letzten 150 Jahren eine Behandlung entwickelt hat, durch die Krebs und andere Krankheiten auf natürliche Weise geheilt werden. In Begegnungen mit Wissenschaftlern und Ärzten zeigt sich, dass auch die westliche Forschung in der Nano-Medizin ein neues Verständnis von Krebs entwickelt und nach Wegen aus der Sackgasse der bisherigen Therapien sucht. Die sensationellen Erfolge der Banerjis können helfen, die Angst vor Krebs zu überwinden und der Krebsforschung zu einem ganzheitlichen Verständnis der Krankheit zu führen.

This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews.Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

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Cancer has been the driving force behind innumerable studies, leading to the discovery of oncogenes (or cancer-causing genes) and helping us understand the inner world of the cell. This knowledge has not only provided us with the ammunition we need to fight cancer, it has also paved the way for many powerful therapies that will someday rid the world of other noxious diseases, including AIDS, Alzheimer's disease, and the infirmities that strike us as we grow old. Cancer, Revised Edition explores the many facets of cancer research, from basic genetic and cellular mechanisms to the danger of carcinogens and the influence of lifestyle. This edition contains updated and revised material throughout, three new chapters, and many new drawings and photographs, all of which are now in full color.

This volume, a state-of-the-art review of early phase clinical trials for cancer immunotherapy, discusses biomarker selection, combinatorial strategies and their safety or toxicity, determination of Phase 2 dosing, endpoints in the setting of radiographic pseudoprogression, histology selection, and novel immunotherapeutics as they relate to early phase cancer immunotherapy.

MERCI HANDY - KOLLEKTION TIERKREISZEICHEN Die Handreinigungsgele der Marke Merci Handy sind Kosmetikprodukte, deren Funktion darin besteht, Deine Hände zu reinigen, nicht aber zu desinfizieren: Sie haben keine antibakterielle Wirkung - Modellname: ASTRO - Produktgröße: 30 ml - Marke: Merci Handy

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This book shows how a bioinformatics approach has been used to characterize various cancer-related processes. It provides a historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments.

One in a series introducing young readers to conditions and disabilities that may affect them, or their friends and family. KS1.

Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.

This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression.The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeuticrationale.

A detailed account of Rife's inventions and discoveries is the subject of The Cancer Cure That Worked. This startling book documents events from 1913 to the time of Rife's death in 1972. Rife was an optical engineer and technician of great skill. His first success was the building of the Universal Microscope in the late 1920s. With it he was able to view the living cancer virus -- a feat our modern, high-powered electron microscopes still cannot do. His microscope used many quartz prisms and lenses, placed to compensate for losses of refraction due to air. This enabled him to view far tinier particles than had ever been seen before. Using the Universal Microscope which he invented, he observed cancer viruses as they changed their size and form. He discovered that exposing a virus to certain frequencies of radio waves killed it quickly. Years of experimentation led to Rife's invention of the Frequency Instrument, a device that produced the exact frequencies needed to destroy various viruses. In 1934 at the clinic in California, diseased people were exposed to the exact same frequencies that had been seen (through the microscope) to destroy the virus causing their illness. Treatments lasted only three minutes. The person would wait three days before another exposure giving the lymph system time to cleanse the dead virus from their bodies. Unlike the chemotherapy treatments currently in use, Rife's therapy was 100 percent effective and engendered no adverse symptoms. Yet, 53 years after the arrival of Rife's Frequency Instrument, hundreds of thousands of people still die each year of diseases that Royal Raymond Rife cured. The above is excerpted from a book review written by Deki and Jon C. Fox.

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The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor's localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.

Cancer has been the driving force behind innumerable studies, leading to the discovery of oncogenes (or cancer-causing genes) and helping us understand the inner world of the cell. This knowledge has not only provided us with the ammunition we need to fight cancer, it has also paved the way for many powerful therapies that will someday rid the world of other noxious diseases, including AIDS, Alzheimer's disease, and the infirmities that strike us as we grow old. Cancer, Revised Edition explores the many facets of cancer research, from basic genetic and cellular mechanisms to the danger of carcinogens and the influence of lifestyle. This edition contains updated and revised material throughout, three new chapters, and many new drawings and photographs, all of which are now in full color.