Es wurden 49 Produkte zu dem Suchbegriff ubiquiti in 3 Shops gefunden:
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Ubiquitin, Kartoniert (TB)
Anbieter: Weltbild CH Preis: 177,00 CHFUbiquitin. Softcover reprint of the original 1st ed. 1988
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Ubiquitin, Kartoniert (TB)
Anbieter: Weltbild.ch Preis: 177,00 CHFUbiquitin. Softcover reprint of the original 1st ed. 1988
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Ubiquitin-Proteasome Protocols, Kartoniert (TB)
Anbieter: Weltbild CH Preis: 118,00 CHFA collection of cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome-dependent functions. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes. The targeted addition of ubiquitin to proteins is now known to regulate many cellular events, with the enzymes involved in protein ubiquitination linked to a variety of clinical problems, such as cancer, heart disease, and immune dysfunction. In Ubiquitin-Proteasome Protocols, hands-on leaders in the field, many of whom originally developed the methods they describe, detail cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome- dependent functions. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.
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Ubiquity
Anbieter: Fr.fnac.ch Preis: 25,90 CHFUbiquity - Vinyle album - Musique CD, Vinyl : tous les albums pop, rock, variété, rap, R'n'B, classique, jazz, metal, electro ...
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The Ubiquitin Code, Kartoniert (TB)
Anbieter: Weltbild CH Preis: 153,50 CHFThis volume details novel and popular approaches to decipher the Ubiquitin Code. Chapters guide readers through ubiquitin chain complexity, methods to generate non-hydrolysable ubiquitin-NEDD8, a fully synthetic method for the linear synthesis of fluorescently labelled rhodamine LC3A and LC3B, a HECT ligase-mediated ubiquitylation in vitro, a RNAi-based screening to identify DUBs, a Yuh1 activity assay, a pull-down to isolate K48 and K63 chains using specific nanobodies, identification of NeDDylated protein based in a NEDD8R74K mutant, in vivo identification of NEDDylated proteins from liver diseases, UbL-ID method to identify ubiquitin-like modified proteins, a LC3/GABARAP capturing system, and methods to isolate peptides that are closely associated with proteasomes or trapped inside the core particle of proteasomes in eukaryotic cells, among others. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Ubiquitin Code aims to to be a useful practical guide to researches to help further their study in this field.
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Ubiquitin And The Biology Of The Cell, Kartoniert (TB)
Anbieter: Weltbild.ch Preis: 236,00 CHFThe last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.
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The Ubiquitin Proteasome System, Kartoniert (TB)
Anbieter: Weltbild CH Preis: 200,50 CHFThis volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, The UbiquitinProteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.
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Import Ubiquity
Anbieter: Fr.fnac.ch Preis: 26,90 CHFUbiquity - CD album - Musique CD, Vinyl : tous les albums pop, rock, variété, rap, R'n'B, classique, jazz, metal, electro ...
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Ubiquitin Family Modifiers And The Proteasome, Kartoniert (TB)
Anbieter: Weltbild CH Preis: 181,50 CHFThis volume presents novel developments in UPS research and important methods related to recent advances in the field. The volume focuses on the enzymology and substrate identification of ubiquitin family modifiers, the recognition and chain formation of these modifiers, and more.
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Ubiquity Records So far
Anbieter: Fr.fnac.ch Preis: 37,90 CHFSo far - Vinyle album - Musique CD, Vinyl : tous les albums pop, rock, variété, rap, R'n'B, classique, jazz, metal, electro ...
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Ubiquitin Chains: Degradation And Beyond - Arnab De, Kartoniert (TB)
Anbieter: Weltbild CH Preis: 118,00 CHFThis thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo. The case for regulatory ubiquitination has been to a large extent predicated upon the presumed deubiquitinase activity of A20, long considered a key regulator of inflammatory responses as mice lacking A20 die from multi-organ inflammation and cachexia. The theses reports the creation and characterization of a knock-in mouse that expresses a mutated form of A20 which selectively lacks the deubiquitinase activity. The knock-in mice surprisingly display completely normal NF- B activation with no accompanying inflammatory phenotype. Given that the presumed role of A20 as a deubiquitinase has been used to support the importance of regulatory K63-linked ubiquitination in NF-kB signaling, this study will help focus future research efforts into alternative target pathways that do not depend on K63 ubiquitination. In fact, the work suggests that it might be important to revisit the role of K63-linked polyubiquitination in cell-signalling. Ubiquitin Chains: Degradation and Beyond is essential reading for anyone conducting research in cell-signalling and immunology. Dr. Arnab De received his PhD from the Department of Microbiology & Immunology at Columbia University. During his PhD, he developed transgenic mice to study the mechanism of action of a critical tumor-suppressor called A20. He is also well known for having developed peptide-based prodrugs as therapeutics for diabetes. His work has been reported by the media, and has resulted in multiple patents and publications in peer reviewed journals. He presented his findings at the American Peptide Symposium and wasawarded the Young Investigator's Award. He is the author of the book entitled Application of Peptide-Based Prodrug Chemistry in Drug Development, with a foreword written by Professor Jean Martinez (Former President, European Peptide Society) and published in the series SpringerBriefs in Pharmaceutical Science & Drug Development. His research interests lie at the intersection of chemistry and medicine. Besides biomedical research, he is also generally interested in public health policy and general scientific outreach.
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Ubiquity Records So far
Anbieter: Fr.fnac.ch Preis: 26,90 CHFSo far - CD album - Musique CD, Vinyl : tous les albums pop, rock, variété, rap, R'n'B, classique, jazz, metal, electro ...
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Conjugation And Deconjugation Of Ubiquitin Family Modifiers, Kartoniert (TB)
Anbieter: Weltbild CH Preis: 177,00 CHFThe articles in this book are focused on the modifiers ubiquitin, SUMO1/2/3, NED 8, ISG15 and FAT10. They discuss how conjugation enzymes determine specific linkages and how they are interpreted by ubiquitin binding domains.
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Ubiquity Records Fix
Anbieter: Fr.fnac.ch Preis: 26,90 CHFFix - Vinyle album - Musique CD, Vinyl : tous les albums pop, rock, variété, rap, R'n'B, classique, jazz, metal, electro ...
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Ubiquitin And The Biology Of The Cell, Kartoniert (TB)
Anbieter: Weltbild CH Preis: 236,00 CHFThe last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.
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Ubiquity Records The Find
Anbieter: Fr.fnac.ch Preis: 29,90 CHFThe Find - CD album - Musique CD, Vinyl : tous les albums pop, rock, variété, rap, R'n'B, classique, jazz, metal, electro ...
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Ernst Schering Foundation Symposium Proceedings / 2008/1 / The Ubiquitin System In Health And Disease, Kartoniert (TB)
Anbieter: Weltbild CH Preis: 177,00 CHFThe ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in?ammation, central nervous system disorders, and metabolic dysfunction. Ubiquitin is a highly conserved 76-amino acid protein which is transferred to its target protein in an ATP-dependent manner. This post-translational modi?cation takes place in a hierarchical, three-step fashion involving an E1 ubiquitin-activating enzyme, an E2 ubiquit- conjugating enzyme, and an E3 ubiquitin ligase. Substrate speci?city is predominantly controlled by members of a large family of E3 - zymes, which form complexes with the proteins that will be modi?ed. This ultimately leads to the covalent attachment of the C-terminus of ubiquitin to usually an?-amino group of a lysine residue in the targeted protein. Additional ubiquitin transfer to lysine-48 of ubiquitin itself will form a polyubiquitin chain, which usually targets the conjugate for degradation by the proteasome. By contrast, mono- or polyubiquityla- VI Preface tion involving lysine-63 is normally involved in the control of protein activity. Ubiquitylation can be reverted by deubiquitylating enzymes, of which approximately 95 exist in mammals.
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Ubiquity Back from Havana
Anbieter: Fr.fnac.ch Preis: 23,90 CHFBack from Havana - CD album - Musique CD, Vinyl : tous les albums pop, rock, variété, rap, R'n'B, classique, jazz, metal, electro ...
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Import Ubiquitous
Anbieter: Fr.fnac.ch Preis: 19,90 CHF (+5,00 CHF)Ubiquitous - CD album - Musique CD, Vinyl : tous les albums pop, rock, variété, rap, R'n'B, classique, jazz, metal, electro ...
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Ubiquity Records City to city
Anbieter: Fr.fnac.ch Preis: 34,90 CHFCity to city - Vinyle album - Musique CD, Vinyl : tous les albums pop, rock, variété, rap, R'n'B, classique, jazz, metal, electro ...
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