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Puma-Kollektion: Produktcode: ZLN 0560 Unisex-Modell, Farbe: Gelb, Stil: lässig, sportlich, Material: Kunstleder, andere Materialien, Details: geprägtes Logo, kontrastierende Details, herausnehmbare Einlegesohlen, Verschluss: Schnürsenkel, Linie: Puma, Zusammensetzung außen: Kunstleder, andere Materialien, innen: Textil, Sohle: andere Materialien, Spitze: rund

Puma-Kollektion: Produktcode: ZLN 0560 Unisex-Modell, Farbe: Gelb, Stil: lässig, sportlich, Material: Kunstleder, andere Materialien, Details: geprägtes Logo, kontrastierende Details, herausnehmbare Einlegesohlen, Verschluss: Schnürsenkel, Linie: Puma, Zusammensetzung außen: Kunstleder, andere Materialien, innen: Textil, Sohle: andere Materialien, Spitze: rund

Puma-Kollektion: Produktcode: ZLN 0560 Unisex-Modell, Farbe: Gelb, Stil: lässig, sportlich, Material: Kunstleder, andere Materialien, Details: geprägtes Logo, kontrastierende Details, herausnehmbare Einlegesohlen, Verschluss: Schnürsenkel, Linie: Puma, Zusammensetzung außen: Kunstleder, andere Materialien, innen: Textil, Sohle: andere Materialien, Spitze: rund

Puma-Kollektion: Produktcode: ZLN 0560 Unisex-Modell, Farbe: Gelb, Stil: lässig, sportlich, Material: Kunstleder, andere Materialien, Details: geprägtes Logo, kontrastierende Details, herausnehmbare Einlegesohlen, Verschluss: Schnürsenkel, Linie: Puma, Zusammensetzung außen: Kunstleder, andere Materialien, innen: Textil, Sohle: andere Materialien, Spitze: rund

Puma-Kollektion: Produktcode: ZLN 0560 Unisex-Modell, Farbe: Gelb, Stil: lässig, sportlich, Material: Kunstleder, andere Materialien, Details: geprägtes Logo, kontrastierende Details, herausnehmbare Einlegesohlen, Verschluss: Schnürsenkel, Linie: Puma, Zusammensetzung außen: Kunstleder, andere Materialien, innen: Textil, Sohle: andere Materialien, Spitze: rund

This volume is based on the proceedings of an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) held October 1984 in Corfu, Greece. The meeting received finan­ cial support from the United States Department of Energy and the United States National Cancer Institute. A plethora of recent developments in the molecular biology of DNA are leading to new ideas concerning how DNA alterations might be involved in the mechanism of radiation carcinogenesis. Evidence is accumulating that genetic sequences, known as oncogenes, are involved in the translation of DNA molecular alterations into phenotypic changes associated with malignant cells. For example, a chromosome break often occurs at or near the loca­ tion of a specific oncogene in Burkitt's lymphoma. Such breaks could represent initial lesions in a translocation process that activates the oncogene by inserting it at a new location, eg., near an active pro­ moter. Since breakage of the DNA is one of the principal ways that ion­ izing radiation affects mammalian cells, these new molecular ideas sug­ gest ways that radiation-induced DNA breaks might be involved as initial events in carcinogenesis. While the possible involvement of oncogenes in radiation carcino­ genesis is an exciting new development, a direct sequential connection between early molecular changes in DNA and later tumor development has yet to be established. Accordingly, there is a tremendous need for experimental studies of how DNA alterations might convert normal cells to cancer cells.

Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.

Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.

In neurosciences one may say, '"All roads lead to Rome. " It seems as though wherever one starts, the course of investigation leads to the same major ques­ tions about nervous system function and dysfunction. In thinking about what to write in this preface, it occurred to me that it might be best to deal with that with which I am most familiar and to trace to some extent my own '"road to Rome. '' As I look over my work of the last 37 years, it becomes clear to me that it can be epitomized as a search for patterns. What usually began as a single­ minded devotion to in-depth analysis of one or a small number of variables always has led to questions of how the results might relate to the whole living unit, whether it is cell, tissue, or organism. For a number of years after my discovery in the vertebrate central nervous system of -y-aminobutyric acid (GABA) and the enzyme which forms it, L­ glutamate decarboxylase (GAD), and the identification of GABA as a major inhibitory neurotransmitter by others, I felt that my laboratory, largely bio­ chemical, was wandering in the wilderness of the complexities of the vertebrate CNS without definitively coming to terms with problems related to GABAergic transmitter functions and the roles of GABA neurons in information processing.

Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.

Das Magic Keyboard ist der perfekte Begleiter für das iPad Air. Es hat ein schlankes, mobiles Design und sorgt für ein angenehmes Tippen. Und du hast ein Trackpad, um ganz präzise zu arbeiten. Die Tastatur hat eine Reihe mit 14 Funktions­tasten, einen USB-C Anschluss zum Pass-Through Laden sowie einen Schutz für die Vorder- und Rückseite deines iPad. Das frei­schwebende Design lässt sich stufenlos an mehrere Betrachtungs­winkel anpassen und ein großes Trackpad aus Glas gibt dir neue Möglichkeiten, mit iPadOS zu arbeiten. Für einen perfekten Betrachtungs­winkel lässt sich das mobile, frei­schwebende Design stufenlos anpassenDas große Trackpad aus Glas ist reaktions­schnell und intuitiv bedienbarDie Reihe mit 14 Funktions­tasten lässt dich auf die Helligkeit des Displays, die Laut­stärke und andere Features zugreifenKomfortables Tippen mit einem Scheren­mechanismus mit 1 mm TastenhubGemacht für Multi-Touch Gesten und den Cursor in iPadOSUSB-C Anschluss zum Laden des iPad Air. Dadurch ist der Anschluss am iPad frei für anderes ZubehörLässt sich in ein Case falten, das Vorder- und Rückseite schützt, wenn du mit dem iPad Air unterwegs bist AllgemeinTastaturaufbauQWERTYTastaturspracheUS EnglischEingabegerätTrackpadMarkenkompatibilitätAppleKompatibilitätiPad Air 11-inch (M3) iPad Air 11-inch (M2) iPad Air (5th generation) iPad Air (4th generation)ProduktfarbeWeißVerpackungsbreite212 mmVerpackungstiefe271 mmVerpackungshöhe27 mm TastaturTastaturaufbauQWERTYTastaturspracheUS EnglischTastatur-SwitchScherenschalterEingabegerätTrackpadNumerisches KeypadNeinMultimedia-TastenJaLeistungenMarkenkompatibilitätAppleKompatibilitätiPad Air 11-inch (M3) iPad Air 11-inch (M2) iPad Air (5th generation) iPad Air (4th generation)ProduktfarbeWeißMaximale Bildschirmgröße27,9 cmAbdeckungJaHintergrundbeleuchtungNeinEnergieUSB Typ-C LadeportJaVerpackungsdatenVerpackungsbreite212 mmVerpackungstiefe271 mmVerpackungshöhe27 mmPaketgewicht1,03 kg Tastaturaufbau:QWERTYTastatursprache:US EnglischEingabegerät:TrackpadTastatur-Switch:ScherenschalterMultimedia-Tasten:JaMarkenkompatibilität:AppleKompatibilität:iPad Air 11-inch (M3) iPad Air 11-inch (M2) iPad Air (5th generation) iPad Air (4th generation)Produktfarbe:WeißAbdeckung:JaMaximale Bildschirmgröße:27,9 cm (11")USB Typ-C Ladeport:JaVerpackungsbreite:212 mmVerpackungstiefe:271 mmVerpackungshöhe:27 mmPaketgewicht:1,03 kg Allgemeine InformationenHersteller:Apple, IncHersteller-Artikelnummer:MDFV4LB/AHersteller-Webseite:Marke:AppleProduktlinie:MagicProduktbezeichnung:Tastatur/Cover MagicProdukttyp:Tastatur/CoverProduktinformationenDruckdesign/Muster/Textur:AuslegerFunktionsmerkmale:Integrierter TrackpadUSB-LadeanschlussFaltbarMaximal unterstützte Bildschirmgröße:27,9 cm (11 Zoll)Abmessungen / Gewicht / FarbeFarbfamilie:WeißProduktfarbe:WeißSonstigesAnwendung/Gebrauch:TabletMarkenkompatibilität:AppleTablet-Modellkompatibilität:iPad Air 11 (2024)iPad Air (4. Generation)iPad Air (5. Generation)1 Jahr(e) Apple Magic Keyboard - Tastatur und Foliohülle - mit Trackpad - Apple Smart connector - QWERTY - US-Englisch - für 10.9-inch iPad Air (4. Generation, 5. Generation)| 11-inch iPad Air (M2, M3)

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

Abschließbare und um 90 Grad drehbare Wandhalterung. Ladestation. Fotorahmen - Alles in einem. Vorder- und Rückseite aus eloxiertem Aluminium. Restliche Teile aus hochwertigstem,...

Abschließbare und um 90 Grad drehbare Wandhalterung. Ladestation. Fotorahmen - Alles in einem. Vorder- und Rückseite aus eloxiertem Aluminium. Restliche Teile aus hochwertigstem, teilweise zusätzlich verstärktem Kunststoff. Abschließbar - Im Büro, auf Messen, im Hotel oder in öffentlichen Einrichtungen ist das iPad dank eines Schlosses sicher vor "Langfingern". Das Schloss ermöglicht nur denen Zugriff aufs iPad, die ihn auch tatsächlich haben sollen. Das Schloss ist standardmäßig dabei. Mit nur einem Handgriff ist das iPad so ins sDock eingefügt, dass es weiterhin nutzbar oder aufladbar ist. Einsetzen: Erst oben einklinken, dann unten. Fertig. Herausnehmen: Einfach kurz nach oben drücken. Rausnehmen. Kinderleicht. Das sDock pro ist schnell und einfach montiert. Es kann im Hochformat, Querformat oder drehbar an die Wand montiert werden. Unterputz - Stromversorgungen dazu optional erhältlich. (230 V Netzstrom S24 / Unterputz-Netzteil oder PoE) Eine Stromversorgung ist nicht im Lieferumfang enthalten. Vorder- und Rückseite aus eloxiertem Aluminium. Restliche Teile aus hochwertigstem, teilweise zusätzlich verstärktem Kunststoff.

iPad Mini6 2021(8.3-inch),Samsung Galaxy Tab S8 2022(11-inch),Samsung Galaxy Tab S8+ 2022(12.4-inch),Samsung Galaxy Tab S7 2020(11-inch),Samsung Galaxy Tab S7 FE 2021(12.4-inch),Samsung Galaxy Tab S6 Lite 2020/2022/2024 (10.4-inch),iPad 10 2022(10.9-inch),iPad 9.7 5. 6,iPad Air 4 5 10.9,Samsung Galaxy Tab S7 Plus,Samsung Galaxy Tab S9/S9FE,Samsung Galaxy Tab A9 Plus 2023(11-inch),Samsung Galaxy Tab A9 2023(8.7-inch),iPad Pro 11" 2020-2022,iPad 10.2 7. 8. 9,iPad Air6(M2)2024(11-inch),iPad Air6(M2)2024(13-inch),iPad Pro 11(M4)2024(11-inch),iPad Pro 13(M4)2024(13-inch),Xiaomi Redmi Pad Pro 2024(12.1-inch),Samsung Galaxy Tab S9+ 2023(12.4-inch),Samsung Galaxy TAB S10 Plus 12.4,iPad Air 13(M3 2025),iPad (A16) 11 inch 11th Generation 2025,iPad Air 7(M3)2025(11-inch),Samsung Galaxy Tab A11+ 2025(11-inch),Samsung Galaxy Tab S11 2025(11-inch),Redmi Pad 2 2025(11-inch),Redmi Pad Se 2023(11-inch),Samsung Galaxy Tab S10 Lite 2025(10.9-inch),Samsung Galaxy Tab S10 FE 2025(10.9-inch),iPad Air 8 (M4) 2026 (13 Zoll),iPad Air 8 (M4) 2026 (11 Zoll)Cartoons,BuchstabenPMMA

Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.

Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.

Due to sensitive molecular biological techniques, our understanding of chromosomal aberrations is steadily increasing. Provided here is a review of basic and applied aspects of the field. Chromosome structure, induction of DNA lesions by different clastogenic agents and their repair, induction of aberrations by agents which affect specific sequences in the DNA, and factors affecting induction and yield of chromosomal aberrations are covered. Further, topics such as automation of aberration scoring, problems associated with using chromosomal aberrations and micronuclei in population monitoring and the importance of chromosomal aberration assays in mutagenicity testing of chemicals are included.